Para-aminosalicylic acid plasma concentrations in children in comparison with adults after receiving a granular slow-release preparation.

A C Liwa, H S Schaaf, B Rosenkranz, H I Seifart, A H Diacon, P R Donald

Division of Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa.

Journal of tropical pediatrics 2013 Apr

filter terms:

There are no paediatric data regarding slow-release para-aminosalicylic acid (PAS). We studied PAS plasma concentrations in 10 children receiving a single 150 mg/kg dose daily or 75 mg/kg twice daily and 12 adults receiving 4 g twice daily. Blood specimens pre-dose and 2, 4, 6, 8 and 12 h post-dose from the children and 2, 3, 4, 5, 6, 8 and 12 h post-dose from the adults were analysed by high performance liquid chromatography MS/MS. The mean Cmax in children receiving PAS 75 mg/kg and 150 mg/kg and adults receiving 4 g was 45.40, 56.49 and 51.3 µg/ml, respectively (p = 0.614); the AUC0-12 was 233.3, 277.9 and 368.0 µg/h/ml (p = 0.587). No parameters differed significantly between children and adults nor between the two doses in the same children. A 150 mg/kg PAS dosage given as one or two daily doses leads to plasma concentrations in children similar to those of adults receiving 4 g PAS twice daily.

Citation

A C Liwa, H S Schaaf, B Rosenkranz, H I Seifart, A H Diacon, P R Donald. Para-aminosalicylic acid plasma concentrations in children in comparison with adults after receiving a granular slow-release preparation. Journal of tropical pediatrics. 2013 Apr;59(2):90-4