Rapid detection of Campylobacter antigen by enzyme immunoassay leads to increased positivity rates.

Campylobacter antigen detection by enzyme immunoassay (EIA) provides rapid results compared to traditional culture. However, concern exists regarding specificity. Verification studies of an EIA compared to culture revealed a positive predictive value (PPV) of 91%, whereas PPV fell to 42% during routine diagnostic testing. We suggest all positive EIA results be confirmed via culture.

Citation

Carmen L Giltner, Sandra Saeki, April M Bobenchik, Romney M Humphries. Rapid detection of Campylobacter antigen by enzyme immunoassay leads to increased positivity rates. Journal of clinical microbiology. 2013 Feb;51(2):618-20

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PMID: 23175262

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