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The presence of fluorous substituents can impart a dramatic effect on the efficacy of molecules used for a range of applications in society. Here, we describe the preparation and use of a new trifluoromethylated azomethine ylide precursor, which leads to a series of fluorinated pyrrolidine, 3-pyrroline, and pyrrole building blocks.

Citation

Gaël Tran, Robin Meier, Lawrence Harris, Duncan L Browne, Steven V Ley. Synthesis and use of a trifluoromethylated azomethine ylide precursor. The Journal of organic chemistry. 2012 Dec 21;77(24):11071-8

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PMID: 23176732

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