Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides.

Quorum-sensing (QS) peptides are biologically attractive molecules, with a wide diversity of structures and prone to modifications altering or presenting new functionalities. Therefore, the Quorumpeps database (http://quorumpeps.ugent.be) is developed to give a structured overview of the QS oligopeptides, describing their microbial origin (species), functionality (method, result and receptor), peptide links and chemical characteristics (3D-structure-derived physicochemical properties). The chemical diversity observed within this group of QS signalling molecules can be used to develop new synthetic bio-active compounds.

Citation

Evelien Wynendaele, Antoon Bronselaer, Joachim Nielandt, Matthias D'Hondt, Sofie Stalmans, Nathalie Bracke, Frederick Verbeke, Christophe Van De Wiele, Guy De Tré, Bart De Spiegeleer. Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides. Nucleic acids research. 2013 Jan;41(Database issue):D655-9

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PMID: 23180797

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