Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides.
Evelien Wynendaele, Antoon Bronselaer, Joachim Nielandt, Matthias D'Hondt, Sofie Stalmans, Nathalie Bracke, Frederick Verbeke, Christophe Van De Wiele, Guy De Tré, Bart De Spiegeleer
Drug Quality and Registration (DruQuaR) group, Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, Ghent Hospital University, Ghent B-9000, Belgium.
Nucleic acids research 2013 JanQuorum-sensing (QS) peptides are biologically attractive molecules, with a wide diversity of structures and prone to modifications altering or presenting new functionalities. Therefore, the Quorumpeps database (http://quorumpeps.ugent.be) is developed to give a structured overview of the QS oligopeptides, describing their microbial origin (species), functionality (method, result and receptor), peptide links and chemical characteristics (3D-structure-derived physicochemical properties). The chemical diversity observed within this group of QS signalling molecules can be used to develop new synthetic bio-active compounds.
Citation
Evelien Wynendaele, Antoon Bronselaer, Joachim Nielandt, Matthias D'Hondt, Sofie Stalmans, Nathalie Bracke, Frederick Verbeke, Christophe Van De Wiele, Guy De Tré, Bart De Spiegeleer. Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides. Nucleic acids research. 2013 Jan;41(Database issue):D655-9
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PMID: 23180797
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