DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters.

Natsuko Ichikawa, Machi Sasagawa, Mika Yamamoto, Hisayuki Komaki, Yumi Yoshida, Shuji Yamazaki, Nobuyuki Fujita

Nucleic acids research 2013 Jan

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This article introduces DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated, http://www.bio.nite.go.jp/pks/), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. Bacterial secondary metabolites often show pharmacologically important activities and can serve as lead compounds and/or candidates for drug development. Biosynthesis of each secondary metabolite is catalyzed by a number of enzymes, usually encoded by a gene cluster. Although many scientific papers describe such gene clusters, the gene information is not always described in a comprehensive manner and the related information is rarely integrated. DoBISCUIT integrates the latest literature information and provides standardized gene/module/domain descriptions related to the gene clusters.

Citation

Natsuko Ichikawa, Machi Sasagawa, Mika Yamamoto, Hisayuki Komaki, Yumi Yoshida, Shuji Yamazaki, Nobuyuki Fujita. DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters. Nucleic acids research. 2013 Jan;41(Database issue):D408-14