Rhodium(III)-catalyzed direct oxidative cross coupling at the C5 position of chromones with alkenes.

Rajarshi Samanta, Rishikesh Narayan, Andrey P Antonchick

Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

Organic letters 2012 Dec 7

filter terms:

An atom-economical, Rh(III)-catalyzed, direct oxidative cross-coupling at the C5 position of chromones and flavones with a broad range of alkenes was developed. The products were formed in a highly regioselective manner in good to excellent yields. The developed method was applied in the cross-coupling of natural products for the synthesis of hybrid molecules.

Citation

Rajarshi Samanta, Rishikesh Narayan, Andrey P Antonchick. Rhodium(III)-catalyzed direct oxidative cross coupling at the C5 position of chromones with alkenes. Organic letters. 2012 Dec 7;14(23):6108-11