A historical perspective of aromatase inhibitors for ovulation induction.

Samuel Lunenfeld Research Institute, Department of Physiology, and Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada. casper@lunenfeld.ca

Fertility and sterility 2012 Dec

filter terms:

The concept of using aromatase inhibitors in place of clomiphene citrate (CC) for ovulation induction was introduced >10 years ago; a brief history of its development is presented. Its worldwide usage for ovulation induction, including as an adjunct for intrauterine insemination and in vitro fertilization has occurred despite the absence of definitive data of superiority to CC. The results of two ongoing potentially definitive multicenter trials of efficacy and safety of letrozole compared with CC are eagerly awaited. Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Citation

Robert F Casper, Mohamed F M Mitwally. A historical perspective of aromatase inhibitors for ovulation induction. Fertility and sterility. 2012 Dec;98(6):1352-5