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For decades, platinum drugs have been the mainstay of cancer treatment. However, over time, drug resistance develops, leaving few treatment options. Here we show that platelet-derived growth factor α receptor (PDGF α receptor)-mediated signaling plays a key role in hepatocyte growth factor (HGF) receptor (c-Met) upregulation, which in turn is thought to play an important role in chemotherapy resistance. PDGF α receptor inhibition eliminates cisplatin-dependent Met expression in cervical cancer cell lines. PDGF α receptor inhibitors are widely used in clinical settings, suggesting that the clinical translation of our findings could reduce the suffering of people from drug resistance. Copyright © 2012 Elsevier B.V. All rights reserved.


Shinichiro Kina, Thongsavanh Phonaphonh, Feixin Liang, Hai Kuang, Akira Arasaki, Keiichi Arakaki, Toshiyuki Nakasone, Hajime Sunakawa. PDGF α receptor is a mediator for Cisplatin-induced Met expression. European journal of pharmacology. 2013 Jan 15;699(1-3):227-32

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PMID: 23200895

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