PDGF α receptor is a mediator for Cisplatin-induced Met expression.

Shinichiro Kina, Thongsavanh Phonaphonh, Feixin Liang, Hai Kuang, Akira Arasaki, Keiichi Arakaki, Toshiyuki Nakasone, Hajime Sunakawa

Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan.

European journal of pharmacology 2013 Jan 15

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For decades, platinum drugs have been the mainstay of cancer treatment. However, over time, drug resistance develops, leaving few treatment options. Here we show that platelet-derived growth factor α receptor (PDGF α receptor)-mediated signaling plays a key role in hepatocyte growth factor (HGF) receptor (c-Met) upregulation, which in turn is thought to play an important role in chemotherapy resistance. PDGF α receptor inhibition eliminates cisplatin-dependent Met expression in cervical cancer cell lines. PDGF α receptor inhibitors are widely used in clinical settings, suggesting that the clinical translation of our findings could reduce the suffering of people from drug resistance. Copyright © 2012 Elsevier B.V. All rights reserved.

Citation

Shinichiro Kina, Thongsavanh Phonaphonh, Feixin Liang, Hai Kuang, Akira Arasaki, Keiichi Arakaki, Toshiyuki Nakasone, Hajime Sunakawa. PDGF α receptor is a mediator for Cisplatin-induced Met expression. European journal of pharmacology. 2013 Jan 15;699(1-3):227-32