Regulation of T helper cell subsets by cyclooxygenases and their metabolites.

Hong Li, Matthew L Edin, Artiom Gruzdev, Jennifer Cheng, J Alyce Bradbury, Joan P Graves, Laura M DeGraff, Darryl C Zeldin

Prostaglandins & other lipid mediators 2013 Jul-Aug

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Cyclooxygenases and their metabolites are important regulators of inflammatory responses and play critical roles in regulating the differentiation of T helper cell subsets in inflammatory diseases. In this review, we highlight new information on regulation of T helper cell subsets by cyclooxygenases and their metabolites. Prostanoids influence cytokine production by both antigen presenting cells and T cells to regulate the differentiation of naïve CD4(+) T cells to Th1, Th2 and Th17 cell phenotypes. Cyclooxygenases and PGE2 generally exacerbate Th2 and Th17 phenotypes, while suppressing Th1 differentiation. Thus, cycloxygenases may play a critical role in diseases that involve immune cell dysfunction. Targeting of cyclooxygenases and their eicosanoid products may represent a new approach for treatment of inflammatory diseases, tumors and autoimmune disorders. Published by Elsevier Inc.

Citation

Hong Li, Matthew L Edin, Artiom Gruzdev, Jennifer Cheng, J Alyce Bradbury, Joan P Graves, Laura M DeGraff, Darryl C Zeldin. Regulation of T helper cell subsets by cyclooxygenases and their metabolites. Prostaglandins & other lipid mediators. 2013 Jul-Aug;104-105:74-83