A novel injectable temperature-sensitive zinc doped chitosan/β-glycerophosphate hydrogel for bone tissue engineering.

Ramesh Niranjan, Chandru Koushik, Sekaran Saravanan, Ambigapathi Moorthi, Mariappanadar Vairamani, Nagarajan Selvamurugan

Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, TamilNadu, India.

International journal of biological macromolecules 2013 Mar

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Hydrogels are hydrophilic polymers that have a wide range of biomedical applications including bone tissue engineering. In this study we report preparation and characterization of a thermosensitive hydrogel (Zn-CS/β-GP) containing zinc (Zn), chitosan (CS) and beta-glycerophosphate (β-GP) for bone tissue engineering. The prepared hydrogel exhibited a liquid state at room temperature and turned into a gel at body temperature. The hydrogel was characterized by SEM, EDX, XRD, FT-IR and swelling studies. The hydrogel enhanced antibacterial activity and promoted osteoblast differentiation. Thus, we suggest that the Zn-CS/β-GP hydrogel could have potential impact as an injectable in situ forming scaffold for bone tissue engineering applications. Copyright © 2012 Elsevier B.V. All rights reserved.

Citation

Ramesh Niranjan, Chandru Koushik, Sekaran Saravanan, Ambigapathi Moorthi, Mariappanadar Vairamani, Nagarajan Selvamurugan. A novel injectable temperature-sensitive zinc doped chitosan/β-glycerophosphate hydrogel for bone tissue engineering. International journal of biological macromolecules. 2013 Mar;54:24-9