Hereditary pulmonary alveolar proteinosis. Could it be triggered by Mycoplasma pneumoniae pneumonia?

Paediatric Pulmonology Unit, Paediatric Department, Hospital Universitario de Cruces, Plaza de Cruces s/n, 48903 Barakaldo, Bizkaia, Spain. MIKEL.SANTIAGOBURRUCHAGA@osakidetza.Net

Respiratory medicine 2013 Jan

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We present a three-year-old girl with respiratory failure due to hereditary pulmonary alveolar proteinosis caused by abnormal alpha chain of the granulocyte-macrophage colony-stimulating factor receptor. Both the patient and an asymptomatic seven-year-old sister were homozygous for the same mutation in CSF2RA. We speculate that the Mycoplasma pneumoniae pneumonia might have triggered the clinical presentation. While a good response to serial partial lung lavage was noticed, the ultimate outcome is uncertain. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Mikel Santiago-Burruchaga, Rafael Zalacain-Jorge, Jose Alvarez-Martinez, Jose Mari Arguinzoniz-Marzana, Itziar Pocheville-Guruzeta, Miguel Angel Vazquez-Ronco, Armando Gozalo-García, Carlos Vazquez-Cordero. Hereditary pulmonary alveolar proteinosis. Could it be triggered by Mycoplasma pneumoniae pneumonia? Respiratory medicine. 2013 Jan;107(1):134-8