Mechanism of membrane tube formation induced by adhesive nanocomponents.

Anđela Šarić, Angelo Cacciuto

Department of Chemistry, Columbia University, 3000 Broadway, MC 3123, New York, NY 10027, USA.

Physical review letters 2012 Nov 2

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We report numerical simulations of membrane tubulation driven by large colloidal particles. Using Monte Carlo simulations we study how the process depends on particle size and binding strength, and present accurate free energy calculations to sort out how tube formation compares with the competing budding process. We find that tube formation is a result of the collective behavior of the particles adhering on the surface, and it occurs for binding strengths that are smaller than those required for budding. We also find that long linear aggregates of particles forming on the membrane surface act as nucleation seeds for tubulation by lowering the free energy barrier associated to the process.

Citation

Anđela Šarić, Angelo Cacciuto. Mechanism of membrane tube formation induced by adhesive nanocomponents. Physical review letters. 2012 Nov 2;109(18):188101