Determination sulfamethoxazole based chemiluminescence and chitosan/graphene oxide-molecularly imprinted polymers.

Qiu Huamin, Fan Lulu, Xiangjun Li, Leilei Li, Sun Min, Luo Chuannan

School of Chemistry and Chemical Engineering, University of Jinan, No. 106, Jiwei Road, Jinan 250022, China.

Carbohydrate polymers 2013 Jan 30

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A novel flow injection chemiluminescence (FI-CL) sensor for the determination of sulfamethoxazole (SMZ) was established which using chitosan/graphene oxide-molecularly imprinted polymers (CG-MIP) as recognition element. The SMZ-CG-MIP was synthesized in acetone as solvent and chitosan/graphene oxide for support, using acrylamide as functional monomer, ethylene glycol dimethacrylate as cross-linker and 2,2-azobisisobutyronitrile as initiator. The CG-MIP showed satisfactory recognition capacity for the SMZ. Then the synthesized CG-MIP was employed as recognition by packing into a lab-made tube connected in FI-CL analyzer to establish a novel CL sensor respectively. The CL intensity responded linearly to the concentration of SMZ in the range 1.0 × 10(-7)mol/L to 2.3 × 10(-3)mol/L with a detection limit of 2.9 × 10(-8)mol/L (3σ), which is lower. The relative standard deviation for the determination of 4.0 × 10(-4)mol/L of SMZ was 1.92% (n=11). The sensor is reusable and has a great improvement in sensitivity and selectivity for CL analysis which applied to the determination of SMZ in drug samples. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Qiu Huamin, Fan Lulu, Xiangjun Li, Leilei Li, Sun Min, Luo Chuannan. Determination sulfamethoxazole based chemiluminescence and chitosan/graphene oxide-molecularly imprinted polymers. Carbohydrate polymers. 2013 Jan 30;92(1):394-9