A convenient way to synthesize comb-shaped chitosan-graft-poly (N-isopropylacrylamide) copolymer.

Chen Chen, Mingzhu Liu, Chunmei Gao, Shaoyu Lü, Jiucun Chen, Xiyong Yu, Enyong Ding, Chuanming Yu, Jing Guo, Guijia Cui

State Key Laboratory of Applied Organic Chemistry, and Department of Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.

Carbohydrate polymers 2013 Jan 30

filter terms:

Comb-shaped copolymers comprised of hydrophobic and hydrophilic blocks are self-assembled in aqueous solution, which results that they are suitable for delivery of hydrophobic drug molecules. Chitosan (CS) is an important biomaterial used widely in medical applications. Herein, a comb-shaped cationic copolymer composed of long biocompatible CS main chains and short PNIPAAm side chains was prepared via atom transfer radical polymerization (ATRP) by attaching an ATRP initiating group to N-phthaloyl chitosan. By subsequent removal of the protective groups on N-phthaloyl chitosan-graft-poly(N-isopropylacrylamide) (PHCS-g-PNIPAAm) copolymer with N(2)H(4)·H(2)O lead to the polymer pendant amino groups, this study attempted to synthesize a pH/temperature multi-responsive material. This chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) copolymer is self-assembled in aqueous solution into stimuli-responsive core-shell micelles with hydrodynamic diameters of about 170 nm. Structural organization and solution behavior were then investigated utilizing (1)H NMR spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering (DLS). Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Chen Chen, Mingzhu Liu, Chunmei Gao, Shaoyu Lü, Jiucun Chen, Xiyong Yu, Enyong Ding, Chuanming Yu, Jing Guo, Guijia Cui. A convenient way to synthesize comb-shaped chitosan-graft-poly (N-isopropylacrylamide) copolymer. Carbohydrate polymers. 2013 Jan 30;92(1):621-8