The immunoproteasome in antigen processing and other immunological functions.

Michael Basler, Christopher J Kirk, Marcus Groettrup

Division of Immunology, Department of Biology, University of Konstanz, Universitätsstrasse 10, D-78457 Konstanz, Germany. Michael.Basler@uni-konstanz.de

Current opinion in immunology 2013 Feb

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Treatment of cells with interferon-γ leads to the replacement of the constitutive catalytic proteasome subunits β1, β2, and β5 by the inducible subunits LMP2 (β1i), MECL-1 (β2i), and LMP7 (β5i), respectively, building the so-called immunoproteasome. The incorporation of these subunits is required for the production of numerous MHC class-I restricted T cell epitopes. Recently, new evidence for an involvement of the immunoproteasome in other facets of the immune response emerged. Investigations of autoimmune diseases in animal models and a genetic predisposition of β5i in human autoimmune disorders suggest a crucial function of the immunoproteasome in proinflammatory diseases. The recent elucidation of the high-resolution structure of the immunoproteasome will facilitate the design of immunoproteasome selective inhibitors for pharmacological intervention. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Michael Basler, Christopher J Kirk, Marcus Groettrup. The immunoproteasome in antigen processing and other immunological functions. Current opinion in immunology. 2013 Feb;25(1):74-80