Wei Dai, Shifeng Huang, Shan Sun, Ju Cao, Liping Zhang
Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing 400016, PR China.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2013 MarThe most widespread type of carbapenemases among carbapenem-resistant Acinetobacter baumannii (CRAB) belongs to the oxacillinase (OXA) group. A total of 57 CRAB isolates and 20 non-CRAB isolates (i.e., A. baumannii susceptible to carbapenems) were studied to investigate the molecular epidemiology of CRAB isolates and to identify the OXAs responsible for resistance to imipenem. The ISAba1-blaOXA-23-like gene was detected in all 57 CRAB isolates but was detected in none of the non-CRAB isolates. Pulsed-field gel electrophoresis (PFGE) revealed that clones A and B were the dominant genotypes, and all blaOXA-23-like gene positive strains were classified as either clone A or B strains. ST75 and ST137 were the most prominent sequence types (STs). Finally, the A. baumannii isolates of clone A, C and F were all demonstrated to be genetically similar to the previously identified European clone II. In conclusion, ST75- and ST137-type CRAB isolates that produced the blaOXA-23-like gene with an upstream ISAba1 contributed to the nosocomial outbreaks studied in this work. Copyright © 2012 Elsevier B.V. All rights reserved.
Wei Dai, Shifeng Huang, Shan Sun, Ju Cao, Liping Zhang. Nosocomial spread of carbapenem-resistant Acinetobacter baumannii (types ST75 and ST137) carrying blaOXA-23-like gene with an upstream ISAba1 in a Chinese hospital. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2013 Mar;14:98-101
PMID: 23219422
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