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This article is an overview of bioreactors using tubular membranes such as hollow fibers or ceramic capillaries for cultivation processes. This diverse group of bioreactor is described here in regard to the membrane materials used, operational modes, and configurations. The typical advantages of this kind of system such as environments with low shear stress together with high cell densities and also disadvantages like poor oxygen supply are summed up. As the usage of tubular membrane bioreactors is not restricted to a certain organism, a brief overview of various applications covering nearly all types of cells from prokaryotic to eukaryotic cells is also given here.


Christoph Wolff, Sascha Beutel, Thomas Scheper. Tubular membrane bioreactors for biotechnological processes. Applied microbiology and biotechnology. 2013 Feb;97(3):929-37

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PMID: 23224587

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