Modulation of the coagulation system during severe streptococcal disease.

Oonagh Shannon, Heiko Herwald, Sonja Oehmcke

Division of Infection Medicine, Department of Clinical Sciences, Biomedical Centre, B14, Lund University, Sweden. oonagh.shannon@med.lu.se

Current topics in microbiology and immunology 2013

filter terms:

Haemostasis is maintained by a tightly regulated coagulation system that comprises platelets, procoagulant proteins, and anticoagulant proteins. During the local and systemic response to bacterial infection, the coagulation system becomes activated, and contributes to the pathophysiological response to infection. The significant human pathogen, Streptococcus pyogenes has multiple strategies to modulate coagulation. This can range from systemic activation of the intrinsic and extrinsic pathway of coagulation to local stimulation of fibrinolysis. Such diverse effects on this host system imply a finely tuned host-bacteria interaction. The molecular mechanisms that underlie this modulation of the coagulation system are discussed in this review.

Citation

Oonagh Shannon, Heiko Herwald, Sonja Oehmcke. Modulation of the coagulation system during severe streptococcal disease. Current topics in microbiology and immunology. 2013;368:189-205