Correlation Engine 2.0
Clear Search sequence regions

An increasing number of Gram-negative bacteria have been observed to secrete outer membrane vesicles (OMVs). Many mysteries remain with respect to OMV formation, the regulation of OMV content and mode of targeting and fusion. Bacterial OMVs appear to serve a variety of purposes in intra- and interspecies microbial extracellular activities. OMVs have been shown to mediate cell-to-cell exchange of DNA, protein and small signalling molecules. The impact of such material exchanges on microbial communities and pathogenic processes, including the delivery of toxins at high concentration through OMVs, is discussed. This rather recent aspect of microbial ecology is likely to remain an important area of research as an in-depth understanding of OMVs may allow new approaches for combating bacterial infections and provide new routes for selective drug delivery. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.


James Berleman, Manfred Auer. The role of bacterial outer membrane vesicles for intra- and interspecies delivery. Environmental microbiology. 2013 Feb;15(2):347-54

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 23227894

View Full Text