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  • acetanilide (4)
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    A palladium-catalyzed cascade cross-coupling of acetanilide and toluene for the synthesis of ortho-acylacetanilide is described. Toluene derivatives can act as effective acyl precursors (upon sp(3)-C-H bond oxidation by a Pd/TBHP system) in the oxidative coupling between two C-H bonds. This dehydrogenative Pd-catalyzed ortho-acylation proceeds under mild reaction conditions.


    Yinuo Wu, Pui Ying Choy, Fei Mao, Fuk Yee Kwong. Toluene derivatives as simple coupling precursors for cascade palladium-catalyzed oxidative C-H bond acylation of acetanilides. Chemical communications (Cambridge, England). 2013 Jan 25;49(7):689-91

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    PMID: 23230572

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