Divergent effects of desferrioxamine on bacterial growth and characteristics.

Daisei Eto, Kenta Watanabe, Hisafumi Saeki, Ken-ichi Oinuma, Ko-ichi Otani, Megumi Nobukuni, Hatsumi Shiratori-Takano, Hideaki Takano, Teruhiko Beppu, Kenji Ueda

Life Science Research Center, College of Bioresource Sciences, Nihon University, Kanagawa, Japan.

The Journal of antibiotics 2013 Apr

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Desferrioxamines (DF's) are siderophores produced by some groups of bacteria. Previously, we discovered that DFE, produced by Streptomyces griseus, induced divergent developmental phenotypes in various Streptomyces isolates. In this study, we isolated bacteria whose phenotype was affected by the presence of 0.1 mM DFB from soil samples, and studied their phylogenetic position via 16 S rRNA gene-based analysis. Isolates belonging to Microbacterium grew only in the presence of DFB in the medium. DFB promoted growth of some isolates, while significantly inhibiting that of other divergent bacteria. Different groups of isolates were affected, not because of growth-related changes, but because of changes in the colony morphology based on possible stimulation of motility. An isolate affiliated with Janthinobacterium was stimulated for violacein production as well as for pilus formation. The wide and divergent effects of DFB suggest that availability of siderophores significantly affect the structure of microbial community.

Citation

Daisei Eto, Kenta Watanabe, Hisafumi Saeki, Ken-ichi Oinuma, Ko-ichi Otani, Megumi Nobukuni, Hatsumi Shiratori-Takano, Hideaki Takano, Teruhiko Beppu, Kenji Ueda. Divergent effects of desferrioxamine on bacterial growth and characteristics. The Journal of antibiotics. 2013 Apr;66(4):199-203