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WS1358A1, a novel inhibitor of renal dehydropeptidase (DHP), augmented the urinary recovery of a carbapenem antibiotic imipenem and improved its protective effect in experimental infections when simultaneously administered to mice with the antibiotic. WS1358A1 was a competitive DHP inhibitor with a Ki value of 1.6 x 10(-7) M.


S Hashimoto, H Murai, K Nitta, A Fujie, M Okuhara, M Kohsaka, H Imanaka. Studies on new dehydropeptidase inhibitors. III. Biological properties of WS1358A1. The Journal of antibiotics. 1990 Mar;43(3):281-5

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PMID: 2324012

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