Studies on new dehydropeptidase inhibitors. III. Biological properties of WS1358A1.

S Hashimoto, H Murai, K Nitta, A Fujie, M Okuhara, M Kohsaka, H Imanaka

Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.

The Journal of antibiotics 1990 Mar

filter terms:

WS1358A1, a novel inhibitor of renal dehydropeptidase (DHP), augmented the urinary recovery of a carbapenem antibiotic imipenem and improved its protective effect in experimental infections when simultaneously administered to mice with the antibiotic. WS1358A1 was a competitive DHP inhibitor with a Ki value of 1.6 x 10(-7) M.

Citation

S Hashimoto, H Murai, K Nitta, A Fujie, M Okuhara, M Kohsaka, H Imanaka. Studies on new dehydropeptidase inhibitors. III. Biological properties of WS1358A1. The Journal of antibiotics. 1990 Mar;43(3):281-5