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New 2,3-diaminopropionic acid inhibitors of AGE and ALE formation.
Nicolas Audic, Guy Potier, N André Sasaki
Pharmamens, 9 avenue Théophile Gautier, 75016 Paris, France.
Organic & biomolecular chemistry 2013 Feb 7Sizes of these terms reflect their relevance to your search.
Novel 2,3-diaminopropionic acid-based molecules were synthesised and tested successfully as glyoxal/methylglyoxal scavengers and as AGE inhibitors. Addition of an 8-hydroxyquinoline moiety led to an increase of the overall activity. The compounds tested in this study were also proved to be efficient in trapping ALE precursor malondialdehyde.
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Nicolas Audic, Guy Potier, N André Sasaki. New 2,3-diaminopropionic acid inhibitors of AGE and ALE formation. Organic & biomolecular chemistry. 2013 Feb 7;11(5):773-80
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PMID: 23242031
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