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Lymphocyte-polarized DC1s: Effective inducers of tumor-specific CTLs.
Oncoimmunology 2012 Nov 01Sizes of these terms reflect their relevance to your search.
Activated lymphocytes secrete dendritic cell (DC)-activating cytokines including tumor necrosis factor α and interferon γ, and induce Type-1-polarized DCs (DC1s). Lymphocyte-polarized DC1s secrete high levels of biologically active interleukin-12 (IL-12p70) and CXCL10 and show enhanced CTL-inducing activity. Our data demonstrate the feasibility of using autologous lymphocytes to enhance the immunogenic properties of DCs in a low-cost clinically-compatible process.
Citation
Erik Berk, Pawel Kalinski. Lymphocyte-polarized DC1s: Effective inducers of tumor-specific CTLs. Oncoimmunology. 2012 Nov 01;1(8):1443-1444
PMID: 23243623
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