Iron sulfide catalyzed redox/condensation cascade reaction between 2-amino/hydroxy nitrobenzenes and activated methyl groups: a straightforward atom economical approach to 2-hetaryl-benzimidazoles and -benzoxazoles.

Thanh Binh Nguyen, Ludmila Ermolenko, Ali Al-Mourabit

Centre de Recherche de Gif-sur-Yvette, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France. nguyen@icsn.cnrs-gif.fr

Journal of the American Chemical Society 2013 Jan 9

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Iron sulfide generated in situ from elemental sulfur and iron was found to be highly efficient in catalyzing a redox/condensation cascade reaction between 2-amino/hydroxy nitrobenzenes and activated methyl groups. This method represents a straightforward and highly atom economical approach to 2-hetaryl-benzimidazoles and -benzoxazoles.

Citation

Thanh Binh Nguyen, Ludmila Ermolenko, Ali Al-Mourabit. Iron sulfide catalyzed redox/condensation cascade reaction between 2-amino/hydroxy nitrobenzenes and activated methyl groups: a straightforward atom economical approach to 2-hetaryl-benzimidazoles and -benzoxazoles. Journal of the American Chemical Society. 2013 Jan 9;135(1):118-21