Lipase inhibitory and LDL anti-oxidative triterpenes from Abies sibirica.

Mizuho Handa, Toshihiro Murata, Kyoko Kobayashi, Erdenechimeg Selenge, Toshio Miyase, Javzan Batkhuu, Fumihiko Yoshizaki

Department of Pharmacognosy, Tohoku Pharmaceutical University, Aoba-ku, Sendai, Japan.

Phytochemistry 2013 Feb

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A methanol extract of Abies sibirica Ladeb, a Mongolian medicinal plant, had an inhibitory effect on both lipase activity in mouse plasma and LDL anti-oxidative activity, which are preventative factors for arteriosclerosis. The extract was fractionated by silica gel column chromatography and its active constituents were sought. From lipid soluble fractions, 20 terpenoids including seven hitherto unknown triterpenes were isolated. The latter triterpenes had either a γ-lactone ring with a lactol or a derivative thereof. Their chemical structures were determined by spectroscopic methods. The lipase inhibitory activity and LDL anti-oxidative activity of these compounds were evaluated. Some constituents (either lipase inhibitory or LDL anti-oxidative activities) had moderate inhibitory activities. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Mizuho Handa, Toshihiro Murata, Kyoko Kobayashi, Erdenechimeg Selenge, Toshio Miyase, Javzan Batkhuu, Fumihiko Yoshizaki. Lipase inhibitory and LDL anti-oxidative triterpenes from Abies sibirica. Phytochemistry. 2013 Feb;86:168-75