miRNAs in endothelial cell signaling: the endomiRNAs.

Massimo M Santoro, S Nicoli

Experimental cell research 2013 May 15

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microRNAs (miRNAs) have a pivotal role during the formation and function of the cardiovascular system. More than 300 miRNAs have been currently found within the mammalian genome, however only few specific miRNAs, named endomiRNAs, showed conseved endothelial cell expression and function. In this review we present an overview of the currently known endomiRNAs, focusing on their genome localization, processing and target gene repression during vasculogenesis and angiogenesis. Published by Elsevier Inc.