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A new resin for the solid-phase synthesis of peptide acids was developed. It was based on a linker with two unique features: methoxy groups as the only activating groups of the phenyl ring and a copper(I)-catalyzed Click chemistry reaction to anchor it to the solid support. The efficiency of this new resin in solid phase peptide synthesis was compared with that of Wang resin.


Vida Castro, Hortensia Rodriguez, Fernando Albericio. Wang linker free of side reactions. Organic letters. 2013 Jan 18;15(2):246-9

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PMID: 23270537

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