Lipoxygenase products in the urine correlate with renal function and body temperature but not with acute transplant rejection.

Lipids 2013 Feb

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Acute transplant rejection is the leading cause of graft loss in the first months after kidney transplantation. Lipoxygenase products mediate pro- and anti-inflammatory actions and thus we aimed to correlate the histological reports of renal transplant biopsies with urinary lipoxygenase products concentrations to evaluate their role as a diagnostic marker. This study included a total of 34 kidney transplant recipients: 17 with an acute transplant rejection and 17 controls. LTE4, LTB4, 12-HETE and 15-HETE concentrations were measured by enzyme immunoassay. Urinary lipoxygenase product concentrations were not significantly changed during an acute allograft rejection. Nevertheless, LTB4 concentrations correlated significantly with the body temperature (P ≤ 0.05) 3 months after transplantation, and 12- and 15-HETE concentrations correlated significantly with renal function (P ≤ 0.05) 2 weeks after transplantation. In conclusion, our data show a correlation for LTB4 with the body temperature 3 months after transplantation and urinary 12- and 15-HETE concentrations correlate positively with elevated serum creatinine concentrations but do not predict acute allograft rejection.

Citation

Stephan W Reinhold, Thomas Scherl, Benjamin Stölcker, Tobias Bergler, Ute Hoffmann, Christian Weingart, Miriam C Banas, Dmitrij Kollins, Martin C Kammerl, Bernd Krüger, Bernhard Kaess, Bernhard K Krämer, Bernhard Banas. Lipoxygenase products in the urine correlate with renal function and body temperature but not with acute transplant rejection. Lipids. 2013 Feb;48(2):167-75