Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis.

Kiichi Unoda, Yoshimitsu Doi, Hideto Nakajima, Kazushi Yamane, Takafumi Hosokawa, Shimon Ishida, Fumiharu Kimura, Toshiaki Hanafusa

Department of Internal Medicine I, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka, 569-0801, Japan.

Journal of neuroimmunology 2013 Mar 15

filter terms:

Eicosapentaenoic acid (EPA), one of the n-3 polyunsaturated fatty acids, is a neuroprotective lipid with anti-inflammatory properties. We investigated the possible therapeutic effect of EPA on experimental autoimmune encephalomyelitis (EAE). EAE mice were fed a diet with or without EPA. The clinical EAE scores of the EPA-fed mice were significantly lower than those of the non-EPA mice. In the EPA-treated mice, IFN-γ and IL-17 productions were remarkably inhibited and the expression levels of peroxisome proliferator-activated receptors were significantly enhanced in the CNS-infiltrating CD4T cells. Thus EPA shows promise as a potential new therapeutic agent against multiple sclerosis. Copyright © 2012 Elsevier B.V. All rights reserved.

Citation

Kiichi Unoda, Yoshimitsu Doi, Hideto Nakajima, Kazushi Yamane, Takafumi Hosokawa, Shimon Ishida, Fumiharu Kimura, Toshiaki Hanafusa. Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis. Journal of neuroimmunology. 2013 Mar 15;256(1-2):7-12