Lisa J Edens, Karen H White, Predrag Jevtic, Xiaoyang Li, Daniel L Levy
Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA.
Trends in cell biology 2013 AprCell size varies greatly among different cell types and organisms, especially during early development when cell division is rapid with little overall growth. A fundamental question is how organelle size is regulated relative to cell size. The nucleus exhibits exquisite size scaling during development and between species, and nuclear size is often altered in cancer cells. Recent studies have elucidated mechanisms of nuclear size regulation in a variety of experimental systems, opening the door to future research on how nuclear size impacts upon cell and nuclear function and subnuclear organization. In this review we discuss studies that have clarified nuclear size control mechanisms and how these results have or will contribute to our understanding of the functional significance of nuclear size. Copyright © 2012 Elsevier Ltd. All rights reserved.
Lisa J Edens, Karen H White, Predrag Jevtic, Xiaoyang Li, Daniel L Levy. Nuclear size regulation: from single cells to development and disease. Trends in cell biology. 2013 Apr;23(4):151-9
PMID: 23277088
View Full Text