Transfer of extracellular vesicles during immune cell-cell interactions.

The transfer of molecules between cells during cognate immune cell interactions has been reported, and recently a novel mechanism of transfer of proteins and genetic material such as small RNA between T cells and antigen-presenting cells (APCs) has been described, involving exchange of extracellular vesicles (EVs) during the formation of the immunological synapse (IS). EVs, a term that encompasses exosomes and microvesicles, has been implicated in cell-cell communication during immune responses associated with tumors, pathogens, allergies, and autoimmune diseases. This review focuses on EV transfer as a mechanism for the exchange of molecules during immune cell-cell interactions. © 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.

Citation

Cristina Gutiérrez-Vázquez, Carolina Villarroya-Beltri, María Mittelbrunn, Francisco Sánchez-Madrid. Transfer of extracellular vesicles during immune cell-cell interactions. Immunological reviews. 2013 Jan;251(1):125-42

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PMID: 23278745

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