Adriano Olímpio da Silva, Rosangela da Silva Lopes, Ricardo Vieira de Lima, Camila Santos Suniga Tozatti, Maria Rita Marques, Sérgio de Albuquerque, Adilson Beatriz, Dênis Pires de Lima
Chemistry Sector (LP4), Center of Exact Sciences and Technology, Federal University of Mato Grosso do Sul, 79070-900 Campo Grande, MS, Brazil.
European journal of medicinal chemistry 2013 FebThe discovery and development of essential drugs for Chagas disease is a major concern worldwide. New substituted 1,4-naphthoquinones were synthesized and tested against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. These products exhibited substantial activity against T. cruzi, especially 2-((8E,11Z)-heptadeca-8,11-dienyl)-3-hydroxynaphthalene-1,4-dione (9) with IC(50) of 7.8 μM. Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Adriano Olímpio da Silva, Rosangela da Silva Lopes, Ricardo Vieira de Lima, Camila Santos Suniga Tozatti, Maria Rita Marques, Sérgio de Albuquerque, Adilson Beatriz, Dênis Pires de Lima. Synthesis and biological activity against Trypanosoma cruzi of substituted 1,4-naphthoquinones. European journal of medicinal chemistry. 2013 Feb;60:51-6
PMID: 23279867
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