16(th) IHIW: anti-HLA alloantibodies of the of IgA isotype in re-transplant candidates.

In this multicentre study, sera from 803 retransplant candidates, including 775 kidney transplant recipients, were analysed with regard to the presence and specificity of anti-HLA alloantibodies of the IgA isotype using a modified microsphere-based platform. Of the kidney recipients, nearly one-third (n = 237, 31%) had IgA alloantibodies. Mostly, these antibodies were found in sera that also harboured IgG alloantibodies that could be found in a total of 572 (74%) of patients. Interestingly, IgA anti-HLA antibodies were preferentially targeting HLA class I antigens in contrast to those of the IgG isotype, which targeted mostly both HLA class I and II antigens. Donor specificity of the IgA alloantibodies could be established for over half of the 237 patients with IgA alloantibodies (n = 124, 52%). A further 58 patients had specificities against HLA-C or HLA-DP, for which no information regarding donor typing was available. In summary, these data showed in a large cohort of retransplant candidates that IgA alloantibodies occur in about one-third of patients, about half of these antibodies being donor specific. © 2012 Blackwell Publishing Ltd.

Citation

M-L Arnold, F M Heinemann, P Horn, M Ziemann, N Lachmann, A Mühlbacher, A Dick, A Ender, D Thammanichanond, G F Fischer, S Schaub, M Hallensleben, J Mytilineos, W E Hitzler, C Seidl, I I N Doxiadis, B M Spriewald. 16(th) IHIW: anti-HLA alloantibodies of the of IgA isotype in re-transplant candidates. International journal of immunogenetics. 2013 Feb;40(1):17-20

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PMID: 23280184

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