Pharmacokinetic considerations for targeted drug delivery.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshidashimoadachi-cho, Sakyo-ku, Japan.

Advanced drug delivery reviews 2013 Jan

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Drug delivery systems involve technology designed to maximize therapeutic efficacy of drugs by controlling their biodistribution profile. In order to optimize a function of the delivery systems, their biodistribution characteristics should be systematically understood. Pharmacokinetic analysis based on the clearance concepts provides quantitative information of the biodistribution, which can be related to physicochemical properties of the delivery system. Various delivery systems including macromolecular drug conjugates, chemically or genetically modified proteins, and particulate drug carriers have been designed and developed so far. In this article, we review physiological and pharmacokinetic implications of the delivery systems. Copyright © 2013. Published by Elsevier B.V.

Citation

Fumiyoshi Yamashita, Mitsuru Hashida. Pharmacokinetic considerations for targeted drug delivery. Advanced drug delivery reviews. 2013 Jan;65(1):139-47