Targeting matrix metalloproteinases: design of a bifunctional inhibitor for presentation by tumour-associated galectins.

Marco Bartoloni, Blanca E Domínguez, Elisa Dragoni, Barbara Richichi, Marco Fragai, Sabine André, Hans-Joachim Gabius, Ana Ardá, Claudio Luchinat, Jesús Jiménez-Barbero, Cristina Nativi

Department of Chemistry, University of Florence, Via della Lastruccia, 13 50019 Sesto F.no Firenze, Italy.

Chemistry (Weinheim an der Bergstrasse, Germany) 2013 Feb 4

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A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal-3 simultaneously. This compound might allow the lectin to attract the MMP inhibitor to the tumour site and to block protumoural activities of the lectin at the same time. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Marco Bartoloni, Blanca E Domínguez, Elisa Dragoni, Barbara Richichi, Marco Fragai, Sabine André, Hans-Joachim Gabius, Ana Ardá, Claudio Luchinat, Jesús Jiménez-Barbero, Cristina Nativi. Targeting matrix metalloproteinases: design of a bifunctional inhibitor for presentation by tumour-associated galectins. Chemistry (Weinheim an der Bergstrasse, Germany). 2013 Feb 4;19(6):1896-902