Marco Bartoloni, Blanca E Domínguez, Elisa Dragoni, Barbara Richichi, Marco Fragai, Sabine André, Hans-Joachim Gabius, Ana Ardá, Claudio Luchinat, Jesús Jiménez-Barbero, Cristina Nativi
Department of Chemistry, University of Florence, Via della Lastruccia, 13 50019 Sesto F.no Firenze, Italy.
Chemistry (Weinheim an der Bergstrasse, Germany) 2013 Feb 4A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal-3 simultaneously. This compound might allow the lectin to attract the MMP inhibitor to the tumour site and to block protumoural activities of the lectin at the same time. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Marco Bartoloni, Blanca E Domínguez, Elisa Dragoni, Barbara Richichi, Marco Fragai, Sabine André, Hans-Joachim Gabius, Ana Ardá, Claudio Luchinat, Jesús Jiménez-Barbero, Cristina Nativi. Targeting matrix metalloproteinases: design of a bifunctional inhibitor for presentation by tumour-associated galectins. Chemistry (Weinheim an der Bergstrasse, Germany). 2013 Feb 4;19(6):1896-902
PMID: 23280962
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