Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Capillary electrophoresis-mass spectrometry (CE-MS) is a powerful analytical tool, especially in the case of chiral separations, due to the fact that it combines the high efficiency, short analysis time, and versatility of the CE with the sensitivity, selectivity, and the capacity for the identification of unknown chiral compounds offered by MS detection. This chapter describes three methodologies enabling the chiral separation of cationic and anionic compounds using different strategies, illustrating the most employed approaches used in chiral CE-MS. The first methodology uses the partial filling technique for the enantioseparation of a cationic compound using a neutral cyclodextrin. Secondly, the enantioseparation of a cationic compound using low concentrations of a neutral cyclodextrin under acidic conditions is described. Finally, a methodology for the chiral separation of an anionic compound employing low concentrations of a native cyclodextrin under basic conditions is illustrated.

Citation

Elena Domínguez-Vega, Antonio L Crego, Maria Luisa Marina. Chiral capillary electrophoresis-mass spectrometry. Methods in molecular biology (Clifton, N.J.). 2013;970:429-41

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 23283794

View Full Text