Synthesis of galactothiophosphoesters of uridine and preliminary tests to evaluate their activity against selected glycosyltransferases.

Marta Grec, Piotr Swierk, Gabriela Pastuch-Gawołek, Wiesław Szeja

Silesian University of Technology, Department of Chemistry, Gliwice, Poland. marta.grec@polsl.pl

Acta poloniae pharmaceutica 2012 Nov-Dec

filter terms:

Glycoconjugates (8-13) were obtained in condensation reaction of selectively protected thiophosphoesters of uridine with 2,3,4.6-tetra-O-acetyl-1-thio-beta-D-galactose. In sequence of reactions: selective protection of esculine, glycosylation reaction and deprotecion beta-D-galactopiranoside-(1-4)-esculine (20) was obtained as a model of the product reaction catalyzed by GTs. Prepared glycococnjugates (8-13) were checked using TLC methods in terms of inhibition of bovine milk beta-1,4-galactosyltransferase.

Citation

Marta Grec, Piotr Swierk, Gabriela Pastuch-Gawołek, Wiesław Szeja. Synthesis of galactothiophosphoesters of uridine and preliminary tests to evaluate their activity against selected glycosyltransferases. Acta poloniae pharmaceutica. 2012 Nov-Dec;69(6):1248-58