Neuroprotective effect of resveratrol prophylaxis on experimental retinal ischemic injury.

Anita P Vin, Hanbo Hu, Yougang Zhai, Cynthia L Von Zee, Andrew Logeman, Evan B Stubbs, Jay I Perlman, Ping Bu

Department of Ophthalmology, Loyola University Chicago, Maywood, IL 60153, USA.

Experimental eye research 2013 Mar

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The purpose of the present study was to investigate whether systemically administered resveratrol can protect against acute retinal ischemic reperfusion injury. Two groups of adult male Sprague Dawley rats (n = 6 per group) were used for this study. Resveratrol (30 mg/kg) or an equal volume of vehicle (30% Solutol HS 15 in 0.9% saline) was administered daily for 5 days via intraperitoneal injection. On the third day of treatment, retinal ischemic injury was induced by elevation of intraocular pressure for 45 min. Prior to resveratrol administration and one-week following ischemic insult, retinal function was measured by scotopic electroretinography (ERG). Retinas were harvested and morphologically analyzed one week after ischemic insult. ERG a- and b-wave amplitudes were significantly reduced following ischemic reperfusion injury. Resveratrol treatment attenuated ischemic-induced loss of retinal function. In control vehicle-treated rats, ischemic reperfusion injury elicited marked thinning of inner retinal layers. Resveratrol prophylactic treatment reduced ischemia-mediated thinning of the whole retina and in particular the inner retinal layers. Therefore, resveratrol may have therapeutic value for the management of retinal ischemic disorders. Copyright © 2013 Elsevier Ltd. All rights reserved.

Citation

Anita P Vin, Hanbo Hu, Yougang Zhai, Cynthia L Von Zee, Andrew Logeman, Evan B Stubbs, Jay I Perlman, Ping Bu. Neuroprotective effect of resveratrol prophylaxis on experimental retinal ischemic injury. Experimental eye research. 2013 Mar;108:72-5