Effects of topiramate on dysaesthetic pain in a patient with multiple sclerosis.

Antonio Siniscalchi, Luca Gallelli, Giovambattista De Sarro

Clinical drug investigation 2013 Feb

filter terms:

Dysaesthetic pain is a common neuropathic pain in patients with multiple sclerosis. Both tricyclic antidepressants (i.e., amitriptyline and duloxetine) and antiepileptic drugs (i.e., carbamazepine, gabapentin and pregabalin) represent first-line treatment of neuropathic pain. However, topiramate, an antiepileptic drug, also demonstrated clinical efficacy in these patients. In this report we describe the case of a 42-year-old woman with an 8-year history of multiple sclerosis who developed dysaesthetic pain in the lower limbs, and was successfully treated with topiramate at a final dose of 150 mg/day. About 8 months after beginning topiramate treatment, the patient had not shown any dysaesthetic pain, and no adverse events related to topiramate had been recorded.

Citation

Antonio Siniscalchi, Luca Gallelli, Giovambattista De Sarro. Effects of topiramate on dysaesthetic pain in a patient with multiple sclerosis. Clinical drug investigation. 2013 Feb;33(2):151-4