Targeting DNA damage response: threshold, chromatin landscape and beyond.

Department of Biology, University of Rome Tor Vergata, via della Ricerca Scientifica, I-00133 Rome, Italy. Stefania.Gonfloni@uniroma2.it

Pharmacology & therapeutics 2013 Apr

filter terms:

Cells are continually exposed to DNA assaults from exogenous and endogenous sources. To maintain genomic integrity, cells have evolved a highly conserved mechanism for repairing DNA lesions and, in particular, DNA double strand breaks (DSBs). Emerging evidence indicates that DNA repair/signaling machinery acts in an integrated fashion with chromatin structure at damaged sites. This review focuses on the interplay between histone modifications and the chromatin-mediated response to DNA damage. Copyright © 2012 Elsevier Inc. All rights reserved.