Jean-Marc Bugnicourt, Olivier Godefroy, Jean-Marc Chillon, Gabriel Choukroun, Ziad A Massy
Service de Neurologie, CHU Amiens, Place Victor Pauchet F-80054, Amiens Cedex 1, France. bugnicourt.jean-marc@chu-amiens.fr
Journal of the American Society of Nephrology : JASN 2013 FebEpidemiologic data suggest that individuals at all stages of CKD have a higher risk of developing cognitive disorders and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including direct neuronal injury by uremic toxins, could also be involved, especially in the absence of obvious cerebrovascular disease. We discuss the prevalence and characteristics of cognitive disorders and dementia in patients with CKD, brain imaging findings, and traditional and nontraditional risk factors. Understanding the pathophysiologic interactions between renal impairment and brain function is important in order to minimize the risk for future cognitive impairment.
Jean-Marc Bugnicourt, Olivier Godefroy, Jean-Marc Chillon, Gabriel Choukroun, Ziad A Massy. Cognitive disorders and dementia in CKD: the neglected kidney-brain axis. Journal of the American Society of Nephrology : JASN. 2013 Feb;24(3):353-63
PMID: 23291474
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