Microfluidic methods for forming liposomes.

Dirk van Swaay, Andrew deMello

Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland.

Lab on a chip 2013 Mar 7

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Liposome structures have a wide range of applications in biology, biochemistry, and biophysics. As a result, several methods for forming liposomes have been developed. This review provides a critical comparison of existing microfluidic technologies for forming liposomes and, when applicable, a comparison with their analogous macroscale counterparts. The properties of the generated liposomes, including size, size distribution, lamellarity, membrane composition, and encapsulation efficiency, form the basis for comparison. We hope that this critique will allow the reader to make an informed decision as to which method should be used for a given biological application.