Differential expression of estradiol and estrogen receptor α in severe preeclamptic pregnancies compared with normal pregnancies.

The purpose of this study was to investigate the expression of estradiol and estrogen receptor α (ESRα) in severe preeclamptic (sPE) pregnancies compared with normal pregnancies. Sera and placentas were obtained from i) patients with sPE (n=25) and ii) a normal control group (n=25) who underwent elective Cesarean deliveries. Estradiol expression was assessed by enzyme-linked immunosorbent assays (ELISAs). ESRα expression was assessed by reverse transcription polymerase chain reaction (RT-PCR) analysis and western blot analysis. In preeclamptic pregnancies, estradiol was underexpressed (P<0.05), however, ESRα mRNA and protein levels were increased significantly in comparison with normal pregnancies (P<0.05). These results show that estradiol and ESRα are deregulated in preeclamptic pregnancies, which in turn suggests the involvement of these molecules in the pathogenesis of preeclampsia.

Citation

Guowu Yin, Xiaoming Zhu, Chun Guo, Yang Yang, Tao Han, Lei Chen, Wen Yin, Ping Gao, Huizhong Zhang, Jie Geng, Julei Wang, Liang Liang. Differential expression of estradiol and estrogen receptor α in severe preeclamptic pregnancies compared with normal pregnancies. Molecular medicine reports. 2013 Mar;7(3):981-5

PMID: 23291833

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