Impact of neuropeptide substance P an inflammatory compound on arachidonic acid compound generation.

International journal of immunopathology and pharmacology 2012 Oct-Dec

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There is much evidence that neuropeptide substance P is involved in neurogenic inflammation and is an important neurotransmitter and neurmodulator compound. In addition, substance P plays an important role in inflammation and immunity. Macrophages can be activated by substance P which provokes the release of inflammatory compounds such as interleukins, chemokines and growth factors. Substance P is involved in the mechanism of pain through the trigeminal nerve which runs through the head, temporal and sinus cavity. Substance P also activates mast cells to release inflammatory mediators such as arachindonic acid compound, cytokines/chemokines and histamine. The release of these chemical mediators is crucial for inflammatory response. Among these mediators there are prostoglandins and leukotrines. Here we review the impact of substance P on inflammatory compounds.

Citation

M Nicoletti, G Neri, G Maccauro, D Tripodi, G Varvara, A Saggini, G Potalivo, M L Castellani, M Fulcheri, M Rosati, E Toniato, A Caraffa, P Antinolfi, G Cerulli, F Pandolfi, R Galzio, P Conti, T C Theoharides. Impact of neuropeptide substance P an inflammatory compound on arachidonic acid compound generation. International journal of immunopathology and pharmacology. 2012 Oct-Dec;25(4):849-57