Lambert-Eaton myasthenic syndrome in mixed small cell carcinoma and adenocarcinoma of extrapulmonary origin.

Anna Chang, Han-Cheng Wang, Wei-Chih Hsu

Department of Neurology, Shin-Kong WHS Memorial Hospital, 95 Wen-Chang Road, Shin-Lin District, Taipei, Taiwan.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2013 Apr

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A patient with typical Lambert-Eaton myasthenic syndrome (LEMS) has a clinical manifestation of proximal muscle weaknesses, a larger-than-100% incremental change in repetitive nerve stimulation on high-rate stimulation electrophysiological testing, and a paraneoplastic origin from small cell carcinoma of the lung. Here, we present a patient with an atypical myasthenic syndrome with an oculobulbar-predominant muscle involvement, a borderline incremental change in repetitive nerve stimulation at high frequencies, and a paraneoplastic origin from extrapulmonary mixed small cell carcinoma and adenocarcinoma. The purpose of this report is to emphasize the importance of painstaking scrutiny in the examination of a patient with a less-common presentation of LEMS. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Anna Chang, Han-Cheng Wang, Wei-Chih Hsu. Lambert-Eaton myasthenic syndrome in mixed small cell carcinoma and adenocarcinoma of extrapulmonary origin. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2013 Apr;20(4):604-6