Clozapine: key discussion points for prescribers.

MGH Schizophrenia Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. michelehill1@gmail.com

Clinical schizophrenia & related psychoses 2013 Jan

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Clozapine is the most effective antipsychotic medication for treatment-refractory schizophrenia and is also approved for suicidality in schizophrenia patients. However, it can cause significant medical morbidity and requires intensive medical monitoring once prescribed. Perhaps due to lack of familiarity with its use, it is underused in clinical practice and its initiation often delayed. This article reviews the literature on clozapine in order to measure its potential effectiveness against its adverse effects and ultimately aims to serve as a useful summary for clinicians in their everyday prescribing.

Citation

Michele Hill, Oliver Freudenreich. Clozapine: key discussion points for prescribers. Clinical schizophrenia & related psychoses. 2013 Jan;6(4):177-85