Transient Monoclonal Gammopathy Induced by Disseminated Staphylococcus aureus Infection.

Monoclonal gammopathy reflects a serological disorder suggesting a plasma cell dyscrasia or a B-cell abnormality. However, it may occasionally be encountered as a transient manifestation in the course of several diseases including infections. This is the first reported case of a transient monoclonal gammopathy IgG lambda light chain associated with a Staphylococcus aureus infection that was complicated with renal abscess and vertebral spondylodiscitis in a previously healthy 68-year-old male. We observed a complete resolution of the gammopathy within three months of medical treatment before the entire restoration of all clinical and laboratory findings. Many invasive and cost-intensive diagnostic procedures had preceded the exclusion of a malignancy. The clinical significance and the exact pathogenesis of transient monoclonality are poorly understood and remain a matter of speculation.

Citation

Dimitrios Stoimenis, Christina Spyridonidou, Nikos Papaioannou. Transient Monoclonal Gammopathy Induced by Disseminated Staphylococcus aureus Infection. Case reports in medicine. 2012;2012:607104

PMID: 23304158

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