The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
The Analyst 2013 Feb 21A water-soluble deep cavitand recognized alkylammonium salts, including the drug amantadine hydrochloride, in spiked samples of human urine. The signals of the guests are detected by (1)H NMR upfield of 0 ppm and so occur in a spectroscopic window that is outside of the normal region and distinct from the signals of the biofluid components.
Daniel A Ryan, Julius Rebek. 1H NMR detection of small molecules in human urine with a deep cavitand synthetic receptor. The Analyst. 2013 Feb 21;138(4):1008-10
PMID: 23304698
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