Highly stereoselective synthesis of (Z)- and (E)-chloro-substituted-α-methylene-γ-butyrolactone by possibly controlling cis- and trans-chloropalladation.

Yi Dong, Xiaoyong Guo, Yuanyuan Yu, Gang Liu

Molecular diversity 2013 Feb

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A palladium-catalyzed selective synthesis of cis- or trans-chloro-substituted-α-methylene-γ-butyrolactones from single substrate (propiolic acid) has been realized by controlling cis- or trans-chloropalladation. This method is highly effective for building C-Cl, C-O, and C-C bonds into a one-pot procedure because of its good atom and step efficiency.

Citation

Yi Dong, Xiaoyong Guo, Yuanyuan Yu, Gang Liu. Highly stereoselective synthesis of (Z)- and (E)-chloro-substituted-α-methylene-γ-butyrolactone by possibly controlling cis- and trans-chloropalladation. Molecular diversity. 2013 Feb;17(1):1-7